Abstract Background FK506 (Tacrolimus) is an important immunosuppressant, produced by industrial biosynthetic processes using various Streptomyces species.Considering the complex structure of FK506, it is reasonable to expect complex regulatory networks controlling its biosynthesis.Regulatory elements, present in gene clusters can have a profound i
With a high occurrence rate and high mortality, the treatment of colorectal cancer (CRC) is increasingly attracting the attention of scholars.Hub genes that determine the Bike Accessories - Triathlon phenotypes of CRC become essential for targeted therapy.In the present study, the importance of cyclin-dependent kinases (CDKs) on the occurrence of C
The Constitution of the Republic of Serbia contains a large number of provisions on human rights and freedoms.The Constitution guarantees all three generations of rights.Articles 28 and 29 of the Constitution regulate the following rights: Dealing with a person deprived of liberty and Supplementary rights in case of deprivation of liberty without a
Abstract Introduction Primary total elbow replacement (TER) services in England are being restructured with the goal of centralising care to specialised centres.It is important to monitor the impact of this service redesign.This protocol outlines an intended analysis to provide detailed descriptions of the patients who are receiving primary TER, wh